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| Colombia - Copa Colombia 2008 - Hexagonal A |
| Mié 07-May-2008 | Junior |  | 2 - 1 |  | R. Cartagena |
| | Emerson de Jesús Acuña Juviano | (1) | | Vladimir Javier Hernández Romero | (1) |
| | | (1) | José Manuel Nájera Ríos |
|
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| Colombia - Copa Colombia 2008 - Hexagonal A |
| Mié 07-May-2008 | Magdalena |  | 2 - 0 |  | Valledupar |
| | Alen Palmesano | (1) | | Norwin Alfonso Figueroa | (1) |
| | |
| |
| Colombia - Copa Colombia 2008 - Hexagonal A |
| Mié 07-May-2008 | Barranquilla F.C. |  | 1 - 0 |  | Córdoba |
| | Jossymar Andrés Gómez | (1) |
| | |
| |
| Colombia - Copa Colombia 2008 - Hexagonal B |
| Mié 07-May-2008 | Envigado |  | 0 - 0 |  | Medellín |
| |
| Colombia - Copa Colombia 2008 - Hexagonal B |
| Mié 07-May-2008 | Nacional |  | 1 - 0 |  | Bajo Cauca |
| | Jeison Javier Devos Anaya | (1) |
| | |
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| Colombia - Copa Colombia 2008 - Hexagonal B |
| Mié 07-May-2008 | Pereira |  | 4 - 0 |  | Rionegro |
| | Jaime Andrés Sierra | (2) | | Mario Fernando Jarramillo | (1) | | Carlos Andrés Ramírez | (1) |
| | |
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| Colombia - Copa Colombia 2008 - Hexagonal C |
| Mié 07-May-2008 | Patriotas F.C |  | 1 - 1 |  | Cúcuta |
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| Colombia - Copa Colombia 2008 - Hexagonal C |
| Mié 07-May-2008 | A. Petrolera |  | 2 - 2 |  | Boyacá Chicó |
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| Colombia - Copa Colombia 2008 - Hexagonal C |
| Mié 07-May-2008 | Bucaramanga |  | 2 - 0 |  | R. Santander |
| |
| Colombia - Copa Colombia 2008 - Hexagonal D |
| Mié 07-May-2008 | Millonarios |  | 2 - 0 |  | Santa Fe |
| |
| Colombia - Copa Colombia 2008 - Hexagonal D |
| Mié 07-May-2008 | Academia |  | 2 - 0 |  | Centauros |
| |
| Colombia - Copa Colombia 2008 - Hexagonal D |
| Mié 07-May-2008 | Equidad Seguros |  | 1 - 0 |  | Bogotá F.C. |
| |
| Colombia - Copa Colombia 2008 - Hexagonal E |
| Mié 07-May-2008 | Pasto |  | 1 - 0 |  | Cortuluá |
| |
| Colombia - Copa Colombia 2008 - Hexagonal E |
| Mié 07-May-2008 | América |  | 0 - 1 |  | Cali |
| |
| Colombia - Copa Colombia 2008 - Hexagonal E |
| Mié 07-May-2008 | Depor |  | 2 - 0 |  | Quindío |
| |
| Colombia - Copa Colombia 2008 - Hexagonal F |
| Mié 07-May-2008 | Soacha |  | 2 - 2 |  | Once Caldas |
| |
| Colombia - Copa Colombia 2008 - Hexagonal F |
| Mié 07-May-2008 | Huila |  | 1 - 1 |  | Expreso Rojo |
| |
| Colombia - Copa Colombia 2008 - Hexagonal F |
| Mié 07-May-2008 | Girardot F.C |  | 2 - 6 |  | Tolima |
